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Abortive Migraine Therapy

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Abortive Migraine Therapy

Abortive migraine therapy consists of using medications to alleviate pain and other symptoms caused by a migraine headache. Common drugs used include nonsteroidal anti-inflammatory drugs (NSAIDs), triptans, and ergotamines.

NSAIDs and triptans are commonly prescribed to treat milder headaches, while ergotamines are usually reserved for moderate or severe cases. Some people may require a combination of abortive medications in order to achieve maximum benefit from these drugs.

Antiemetics are drugs used to relieve nausea and vomiting. They can be taken orally or intravenously, with many being prescribed for the treatment of migraines.

Over-the-counter pain killers are frequently used to treat migraines. While they are effective at relieving pain and other symptoms associated with migraines, overdoses can have serious adverse reactions such as gastrointestinal bleeding or liver damage.

Triptans and ergotamines have been known to lead to cardiovascular complications such as heart attack or stroke. Furthermore, they may affect blood vessels in the brain, impairing circulation.

Ergotamine and triptans may cause side effects such as nausea, dizziness, muscle aches and weakness, tingling or itching in the head or neck, chest pain, slower heartbeat, numbness/tingling in arms/legs.

Ergot alkaloids are compounds found in rye fungi that have been scientifically recognized to possess biologic effects. When metabolized, these alkaloids form ergotamine and dihydroergotamine, which have antimigraine effects.

Dihydroergotamine is a semisynthetic derivative of ergotamine created through reduction (hydrogenation) of the double bond in its ergoline ring at 9-10 positions. This medication was approved in the United States in 1946 and has become widely used for treating vascular headaches, particularly abortive therapy for acute migraines.

Ergotamine injections are an effective and secure way to stop migraine attacks, though they may be difficult to administer. Therefore, these drugs should only be administered in adults over 18 years of age as children or elderly patients may find them beneficial.

Some women may worry about ergotamine’s effects on their unborn child, especially when taking large doses. It has been speculated that ergotamine may cause uterine contractions and decrease uterine blood flow, potentially leading to spontaneous abortion or other birth defects.

Ergotamine use may also pose risks such as liver disease, kidney failure and heart failure. Furthermore, it has been speculated that ergotamine may increase the likelihood of coronary artery disease and heart valve disease.

These effects are more frequent in those taking high doses of ergotamine or triptans, but can occur to anyone taking it. If any occur, contact your doctor immediately and inform them of your concerns.

Ergotamines can be minimized risks by taking the proper dosage, monitoring your diet and other factors that might influence how your body responds to them, and other treatments like exercise or resting.

Ergotamine injections have been known to decrease temporal lobe pulsations and alleviate migraine headaches. Furthermore, they reduce oxidative stress while potentially increasing metabolism.

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