Abortive Migraine Therapy During Pregnancy

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Abortive Migraine Therapy During Pregnancy

Migraine is a widespread headache disorder that can affect women during the prenatal period and during breastfeeding. Medication-induced treatments for migraine can reduce their frequency and improve quality of life for affected individuals.

Medication can be taken orally, in injections or through the skin for treating migraine attacks. Some drugs, like ibuprofen and aspirin, have been proven safe during pregnancy while others like triptans should not be used during this time.

Non-drug therapies (relaxation, massage, ice packs and biofeedback) may also be effective for managing migraine in pregnant patients. Any complementary medicines should only be used under medical supervision and recorded in the patient’s notes.

In addition to abortive therapy, pregnant women may find symptom relief by reducing migraine triggers like lack of sleep, stress and poor diet. This is possible through lifestyle changes such as regular exercise and eating a balanced, nutritious diet.

Women who are pregnant may take a variety of medications to treat or prevent migraine headaches, including antidepressants, sedatives and analgesics. However, certain drugs commonly prescribed to treat migraine such as acetaminophen, diphenhydramine and metoclopramide should not be taken during pregnancy due to an increased risk of developing an enlarged liver from these drugs.

Neuromodulation devices, such as nVNS (noninvasive vagus nerve stimulation), have been demonstrated to be successful for treating migraine. Studies have even demonstrated that nVNS can reduce the severity of an acute migraine attack and boost a woman’s pain-relief response by 50% when compared to women on placebo. Furthermore, in one recent study, nVNS was even found to prevent migraine attacks altogether.

Calcitonin gene-related peptide monoclonal antibodies (CGRP monoclonal antibodies) are an alternative type of antimigraine therapy that targets a specific protein in the body. These antibodies can be administered as monthly or quarterly injections and could potentially serve as an option for those suffering from migraine who cannot take conventional antimigraine medication.

The CGRP antibodies (Aimovig, Emgality and Ajovy) target the docking station (receptor) for CGRP receptor, thus blocking its ability to activate a critical signaling pathway in the brain that causes migraine symptoms. Furthermore, these CGRP antibodies may be combined with other migraine prevention therapies for optimal efficacy and safety for patients.

NSAIDs such as aspirin and ibuprofen can be effective for treating acute migraine attacks. These medications should be avoided during the first and second trimesters of pregnancy due to their potential risk for heart attack or stroke.

Other commonly prescribed medications, such as ergotamine, metoclopramide and domperidone are not contraindicated in pregnancy but may pose risks to the infant. Therefore it’s best not to take these during the third trimester since they may cause uterine contractions and miscarriage in expectant mothers.

Other teratogenic medications, such as antihistamines and opiates, should be avoided in pregnant women due to their uterine sensitivity. When considering whether or not a drug is potentially hazardous during pregnancy, the most significant factors include its dosage, route of administration, and timing relative to when the fetal development takes place.

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- Welcome, SoundTherapy.com lowers anxiety 86%, pain 77%, and boosts memory 11-29%. Click on the brain to sign up or share with buttons below to help others: