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Anxious Distress and MDD

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Anxious Distress and MDD

Anxious distress is a clinically important subtype of Major Depressive Disorder (MDD). It has been estimated that 40% to 60% of patients with MDD experience anxiety symptoms. This creates a dangerous cocktail of psychopathology.

Patients with MDD with anxious distress are more likely to be suicidal than those without anxious distress. They also have lower functioning and are less responsive to treatment. In addition, they have an increased risk of cardiovascular disease.

The DSM-5 task force recognized anxiety symptoms in the context of depressive episodes, and added a specifier to identify this subtype of depression. The specifier is based on five self-reported items from two questionnaires: the Inventory of Depressive Symptomatology (IDS) and the Beck Anxiety Inventory.

A new study examined the association between anxious distress and innate cytokine production capacity. Specifically, anxiety features are associated with differential basal inflammation, including LPS-stimulated inflammation. These markers include IL-6, tumor necrosis factor, and monocyte chemotactic protein. However, they were not associated with the BAI score.

Another study examined the relationship between anxious distress and a clinician-rated scale, the DADSI. Patients were scored 0-3, with 0 being no symptoms and 3 being severe symptoms. The DADSI was sensitive to detecting changes in symptoms over the course of the week.

A large sample of MDD patients with concurrent anxiety features were studied. Among these patients, anxious distress was present in 54.3% of the sample, but it was not associated with higher basal inflammation.

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- Welcome, SoundTherapy.com lowers anxiety 86%, pain 77%, and boosts memory 11-29%. Click on the brain to sign up or share with buttons below to help others:

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