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Is sleep deprivation an antidepressant?

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A circadian genomic signature common to ketamine and sleep deprivation in the anterior cingulate cortex. A circadian genomic signature common to ketamine and sleep deprivation in the anterior cingulate cortex. Answers questions about substance abuse, its symptoms, and others. Total sleep deprivation (TSD) has shown an acute antidepressant effect. However, the immediate recurrence of depressive symptoms after sleep recovery has been reported.

Mice with depressive symptoms were given three doses of a compound that triggers adenosine receptors, mimicking sleep deprivation. It works 60 to 70 percent of the time — far better than existing medications — but the mood boost usually only lasts until the patient falls asleep. Although the initial severity of depression did not differ between responders and non-responders, different subjective moods and mood patterns were observed.

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